Stem cells: Living adult tissue transformed back into embryo state

from bbc.co.uk: The living tissue inside an animal has been regressed back into an embryonic state for the first time, Spanish researchers say. 


They believe it could lead to new ways of repairing the body, for example after a heart attack.


However, the study published in the journal Nature, showed the technique led to tumours forming in mice. 


Stem cell experts said it was a “cool” study, but would need to be much more controlled before leading to therapies.


When an egg is first fertilised, it has the potential to develop into every tissue in the human body, from brain cells to skin. 


That flexibility is lost as an embryo develops. However,
transforming adult tissues back into an embryonic-like state may lead to
treatments that can regenerate a weakened heart, or the light-sensing
cells in the eye or even the brain after a stroke.

The transformation has been done in a laboratory, by treating skin samples with a mix of chemicals or genetic modification.

Now scientists at the Spanish National Cancer Research Centre in Madrid have achieved the same results inside an animal.


“It is a surprising result, this was not expected, most of us
thought that it would be impossible,” lead researcher Prof Manuel
Serrano told the BBC.


The research group used mice genetically modified to switch
on, when they were given a specific drug, production of four chemicals
shown to reverse a tissue’s destiny in the laboratory. 


Tissues were successfully transformed back into an embryonic
state, but without further direction they rapidly developed into
tumours. 


Speaking on Science In Action on the BBC World Service, Prof Serrano said: “Of course this is not what we want for regenerative medicine. 


“We want to turn back the clock in a controlled manner and this is something we have to work out in the future.


“We have to find conditions where we reprogramme only partially so that they acquire a plastic state and repair the tissue.”

Prof Robin Ali, from the Institute of Ophthalmology in London, is
using stem cell technology to rebuild the retina to restore sight. He
said the “ultimate goal” would be some treatment that could regenerate
the back of the eye, “but that is a long way off”. 


He added: “This is a really elegant study with important implications for the field. 


“It will be a monumental task to prove this is safe, as what
you’re doing is innately dangerous, but it is exciting as it’s
potentially a new strategy for regenerative medicine.” 

The technique was able to turn the clock back
further than any other stem cell technology, including stem cells taken
from an embryo.


Previous techniques produce stem cells that make the tissues
found in the body. This study could also make those needed to support an
embryo in the womb, such as the placenta. 


Prof Robin Lovell-Badge, from the MRC’s National Institute of
Medical Research, told the BBC that he could not see this technique
leading directly to therapies, but rather improving scientific
understanding.


“To me the interesting thing was the evidence that the cells correspond to an earlier stage of development.


“If we can repeat that with human cells, it would be
incredibly useful and could have important research implications, such
as understanding the placenta and how to help maintain a pregnancy.”



Prof Chris Mason, a stem cell scientist at University College
London, said: “Overall it’s very cool and potentially very exciting,
but it has massive issues in terms of control.”


Instead he thought techniques that transformed cells in the
body directly into the desired tissue would be better than going via
stem cells.


“It’s like a tree, instead of going down from a branch to the
root and back up to a different branch, maybe we’ll be able to jump
from branch to branch.”